SPEAKERS
Jean van den Elsen University of Bath United Kingdom
Arun Kumar Shukla Indian Institute of Technology Kanpur, India
Gregers Rom Andersen Aarhus University Denmark
Christine Gaboriaud Institut de Biologie Structurale France
Thomas H. Sharp Leiden University The Netherlands
Doryen Bubeck Imperial College, London United Kingdom |
Complement, a complex network of proteins and regulators, plays a pivotal role in immune defense, inflammation, and homeostasis. Understanding the structural intricacies of complement components is crucial for unraveling the mechanisms underlying diseases such as autoimmune disorders, infectious diseases, and age-related macular degeneration. Our symposium will explore the latest breakthroughs in this field, shedding light on the atomic-level details of complement proteins, their interactions, and their implications for therapeutic interventions. Whether you are a seasoned structural biologist, a clinician seeking insights into complement-related diseases, or a student eager to explore this exciting field, this symposium offers a unique opportunity to gain deep insights into the structural biology of complement. Organized by Anna Blom, Leendert Trouw and Lubka Roumenina
PROGRAM AGENDA9:00 - 9:05 Introduction
9:05 - 9:35 Jean van den Elsen Structural biology of the complement system; a short history of nearly everything
9:35 - 10:05 Arun Kumar Shukla Molecular mechanism of activation and signaling of complement anaphylatoxin receptors
10:05 - 10:30 Gregers Rom Andersen Structural basis for activation of the alternative pathway
10:30 - 10:45 Break
10:45 - 11:15 Christine Gaboriaud Structural Insights into Classical and Lectin Pathway Recognition and Complex Assembly
11:15 - 11:45 Thomas Sharp Structural biology of complement initiation by the C1 complex
11:45 - 12:15 Doryen Bubeck Regulating the Terminal Pathway |
Organizers |