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Jean van den Elsen

University of Bath

United Kingdom

Arun Kumar Shukla

Indian Institute of Technology

Kanpur, India


Gregers Rom Andersen

Aarhus University


Christine Gaboriaud

Institut de Biologie Structurale


Thomas H. Sharp

Leiden University

The Netherlands

Doryen Bubeck

Imperial College, London

United Kingdom

Complement, a complex network of proteins and regulators, plays a pivotal role in immune defense, inflammation, and homeostasis. Understanding the structural intricacies of complement components is crucial for unraveling the mechanisms underlying diseases such as autoimmune disorders, infectious diseases, and age-related macular degeneration. Our symposium will explore the latest breakthroughs in this field, shedding light on the atomic-level details of complement proteins, their interactions, and their implications for therapeutic interventions.

Whether you are a seasoned structural biologist, a clinician seeking insights into complement-related diseases, or a student eager to explore this exciting field, this symposium offers a unique opportunity to gain deep insights into the structural biology of complement.

Organized by Anna Blom, Leendert Trouw and Lubka Roumenina


9:00 - 9:05



9:05 - 9:35

Jean van den Elsen

Structural biology of the complement system; a short history of nearly everything


9:35 - 10:05

Arun Kumar Shukla

Molecular mechanism of activation and signaling of complement anaphylatoxin receptors


10:05 - 10:30

Gregers Rom Andersen

Structural basis for activation of the alternative pathway


10:30 - 10:45



10:45 - 11:15

Christine Gaboriaud

Structural Insights into Classical and Lectin Pathway Recognition and Complex Assembly


11:15 - 11:45

Thomas Sharp

Structural biology of complement initiation by the C1 complex


11:45 - 12:15

Doryen Bubeck

Regulating the Terminal Pathway



Complement...we are the experts!

ICS promotes advances of complement research and development through the encouragement of cooperative educational programs, clinical applications, and professional standards in the complement field.
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